I think there's a "standard route" for people travelling the 3000km across North America near the 49th parallel. Actually, I think there are two routes.
1) take the Trans-Canada Highway
2) Drop down to the US at some point (some people say the whole way just below the border, some say just to get under the Great Lakes) and hug the border.
I think it would be cool to see some Canadian cities and towns that AREN'T on this well travelled road. Stay off the Highway 1, or at least veer off often and see places that aren't kept alive by a gas station and 4 fast-food joints.
Unfortunately, I think the most exciting cities are probably far north. Talk about Stigmatized, ignored, etc...